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IGF-1 regulates dopamine release from these neurons, and the absence of IGF-1 in dopaminergic neurons decreases dopamine levels in the striatum, leading to deficits in dopamine neuron firing, spontaneous locomotion, and exploratory and learning behaviors (53)

Furthermore, prolonged use results in undesirable side effects like weight increase and the combination of cognitive, autonomic, and motor symptoms that characterise the serotonin syndrome (Pannu and Goyal 2024)

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